General internal disease is a discipline which constitutes a base in all clinical branches of medicine. Most of the problems of patients applying health organizations are within the concern of internal disease. Internal diseases involve a large field such as upper and lower respiratory infections, hyper tension, stomach – intestine diseases, kidney diseases, thyroid gland diseases, diabetes, rheumatic diseases. There is a hard collaboration with all branches related with internal diseases at diagnosis and treatment periods. Patients are sent to related departments by collaborating with cardiology and general surgery departments in the direction of diagnosis which was determined at general internal disease department when necessary and solution of problems of patient is provided. Early diagnosis is quite important for effective treatment and cure concerning the general internal diseases. Diagnosis of many disease are possible with annual check – up services in our day.